Nail changes can give us important clues to some very important underlying systemic diseases. Identifying these changes and correlating them with the patient’s symptoms is very important. Diseases affecting the nails can lead to social, psychological and physical damage. Nails provide protection to the tips of the fingers and toes and help in grasping objects. Nail diseases can be divided into

  • Diseases localized to the nails
  • Nail changes in systemic illnesses

A normal nail is pinkish in color with a nail bed which is whitish and forms a slight angle with the fingers and toes.This article discusses some very important nail abnormalities which should not be missed.

Nail changes in systemic diseases

important nail changes
clubbing of finger nails
  1. Clubbing of the nails:

clubbing of the nails refers to the sponginess and loss of the angle between the nail plate and the finger or toe. Clubbing of the nails may be seen in some families without obvious cause. However, in individuals with normal shaped nails, develop clubbing later in life, a search for an underlying systemic disease may be logical. The following are some of the diseases which have been associated with clubbing.

Cardiovascular diseases:

Important cardiovascular diseases associated with clubbing include

  1. Infective endocarditis:

infections and inflammation of the cardiac valves is called as infective endocarditis. Patients with infective endocarditis usually have a prolonged state of fever and have normal laboratory workup. Infective endocarditis is more common in patients who have rheumatic heart diseases and those with artificial cardiac valves (prosthetic valves). Diagnosis is made on echocardiography and blood cultures and sometimes serological tests are needed. Treatment is with antibiotics for four to six weeks.

2. Cyanotic congenital heart diseases:

patients who have congenital heart diseases with defects in oxygenation may develop clubbing of the fingers and toes. The prime example of cyanotic congenital heart diseases is tetralogy of fallott. These patients, because of a prolonged hypoxic state, usually have high levels of hemoglobin in the body (secondary polycythemia). Diagnosis is usually made early in life with echocardiography. Individuals are usually advised surgical correction of the defect.

3. Patent ductus arteriosus (PDA):

in patients with patent ductus arteriosus, there is differential clubbing of the toe nails with sparing of the finger nails.

4. Eisenmenger syndrome:

patients who have acyanotic congenital heart diseases like ventricular septal defects and atrial septal defects, may develop clubbing later in life when there is reversal of the shunt

Lung diseases:

Lung diseases are also very strongly associated with clubbing. About 29% of the patients with lung cancer have clubbing. The following are few of the important conditions associated with clubbing:

  1. Lung cancer and mesothelioma:

This is one of the serious conditions associated with clubbing. Patients may present with weight loss, skeletal pains, cough and hemoptysis (coughing out blood). Patients may have non-resolving pneumonia or fluid in the peritoneal cavity resistant to treatment.

2. Bronchiectasis:

bronchiectasis is the permanent dilatation of the airways. This leads to defective mucus clearance and repeated infections. Patients have long-lasting cough with copious amount of sputum production which may at times contain blood.

3. Lung abscess and empyema:

Pus collection in the lung parenchyma is called as lung abscess while pus collection in the pleural cavity is called empyema. Patients with lung abscess have very foul smelling sputum production along with swinging fever and chest pain. Patients with empyema have high grade fever and chest pain with shortness of breath.

4. Interstitial lung disease:

Idiopathic pulmonary fibrosis is a disease of the elderly patients. These patients have dry cough with progressively worsening dyspnea and clubbing.

Gastrointestinal causes:

  1. Inflammatory bowel diseases include ulcerative colitis and crohns disease. In both these conditions, patients present with bloody diarrhea and abdominal pain. Diagnosis require colonoscopy with biopsy. Treatment is aimed at immunomodulation.
  2. Cirrhosis: fibrosis with regeneration of the liver parenchyma is called as cirrhosis. Cirrhosis is one of the most prevalent conditions worldwide. Individuals may develop ascites (fluid in the peritoneal/ abdominal cavity), encephalopathy and bloody vomiting.

Miscellaneous causes:

These include tuberculosis, HIV infections and graves disease (also called as thyroid acropachy). Hypertrophic pulmonary osteoarthropathy is another condition with clubbing and thickening of the periosteum of distal phalanx. It may be misdiagnosed as arthritis initially. it may be idiopathic or associated with lung cancer.

nail changes in iron deficiency
koilonychia or spoon nails
  1. Spoon nails or Koilonychia:

Koilonychia or spoon shaped nails as the name suggests is the flattening or loss of convexity of the nails. In severe cases, the nails become concave shaped. These types of nails suggest an underlying diagnosis of iron deficiency anemia. Patients with iron deficiency may present with progressive pallor, shortness of breath on exertion, palpitation, headache and craving for non-food items (PICA).

nail changes in hypoalbuminemia
white nails or leukonychia
  1. Leukonychia:

Leukonychia or white nails is an indirect evidence of reduced albumin (hypoalbuminemia) and proteins (hypoproteinemia) in the body. Hypoalbuminemia and hypoproteinemia may be found in malnutrition, malabsorption, nephrotic syndrome and liver diseases. Patients with liver diseases may have associated pruritis which may lead to shiny nails as well. Leukonychia should be differentiated from the common findings of white lines on the nails or milk line which usually do not have any clinical significance.

nail changes in vasculitis
splinter hemorrhages in infective endocarditis
  1. Splinter hemorrhages or red vertical spots:

Red vertical lines or splinter hemorrhages under the nails develop when micro hemorrhages occur under the nails. These hemorrhages develop when the vessels are fragile as in vasculitis or when clots travel from the heart and block capillaries. Thus, splinter hemorrhages are usually found in infective endocarditis (infection of the heart valves) and when emboli travel from the heart to distant parts of the body.

nail changes in kidney diseases
half and half nails in kidney diseases
  1. Half and half nails:

In these type of nails, the white area of the nail i.e the nail bed occupies half of the nail. This is most commonly seen in patients with kidney diseases and especially those on hemodialysis.

nail changes in old age
terry’s nails in chronic conditions and old age
  1. Terry’s nails:

These nails are almost similar to half and half nails but the whitish area occupies upto 80% of the part. These nails are common in patients with liver diseases, diabetes, kidney dsiseases and patients with congestive cardiac failure.

nail changes in malnutrition
beaus lines in malnutrition
  1. Beaus lines:

These are horizontal depressions in the nails suggestive of transient growth cessation of the nails. These may also be found in hypocalcemia, coronary occlusion, malnutrition and trauma.

nail changes in psoriasis
onycholysis in psoriasis
  1. Onycholysis and pitting of nails:

Separation of nail especially the distal part of the nail from the nail bed is called as onycholysis. It can occur in local skin conditions like fungal infections but can also be found in connective tissue disease, hyperthyroidism and psoriasis. Pitting of the nails is seen in psoriasis and fungal infections.



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