Nail changes – clues to some serious diseases!!

Nail changes can give us important clues to some very important underlying systemic diseases. Identifying these changes and correlating them with the patient’s symptoms is very important.

Diseases affecting the nails can lead to social, psychological and physical damage. Nails provide protection to the tips of the fingers and toes and help in grasping objects. Nail diseases can be divided into

  • Diseases localized to the nails
  • Nail changes in systemic diseases

A normal nail is pinkish in color with a nail bed which is whitish and forms a slight angle with the fingers and toes.

Nail changes in systemic diseases

causes of clubbing
clubbing of fingernails

1. Clubbing of the nails:

Clubbing of the nails refers to the sponginess and loss of the angle between the nail plate and the finger or toe. Clubbing of the nails may be seen in some families without obvious cause.

However, in individuals with normally shaped nails, develop clubbing later in life, a search for an underlying systemic disease may be logical. The following are some of the diseases which have been associated with clubbing.

Cardiovascular diseases:

Important cardiovascular diseases associated with clubbing include:

  1. Infective endocarditis:

Infection and inflammation of the cardiac valves is called infective endocarditis. Patients with infective endocarditis usually have a prolonged state of fever and have normal laboratory workup.

Infective endocarditis is more common in patients who have rheumatic heart diseases and those with artificial cardiac valves (prosthetic valves).

Diagnosis is made on echocardiography and blood cultures and sometimes serological tests are needed. Treatment is with antibiotics for four to six weeks.

2. Cyanotic congenital heart diseases:

patients who have congenital heart diseases with defects in oxygenation may develop clubbing of the fingers and toes.

The prime example of cyanotic congenital heart diseases is tetralogy of fallott. These patients, because of a prolonged hypoxic state, usually have high levels of hemoglobin in the body (secondary polycythemia).

Diagnosis is usually made early in life with echocardiography. Individuals are usually advised surgical correction of the defect.

3. Patent ductus arteriosus (PDA):

In patients with patent ductus arteriosus, there is differential clubbing of the toenails with sparing of the fingernails.

4. Eisenmenger syndrome:

Patients who have acyanotic congenital heart diseases like ventricular septal defects and atrial septal defects may develop clubbing later in life when there is a reversal of the shunt

Lung diseases causing clubbing:

Lung diseases are also very strongly associated with clubbing. About 29% of patients with lung cancer have clubbing. The following are a few of the important conditions associated with clubbing:

  1. Lung cancer and mesothelioma:

This is one of the serious conditions associated with clubbing. Patients may present with weight loss, skeletal pains, cough, and hemoptysis (coughing out blood). Patients may have non-resolving pneumonia or fluid in the peritoneal cavity resistant to treatment.

2. Bronchiectasis:

bronchiectasis is the permanent dilatation of the airways. This leads to defective mucus clearance and repeated infections. Patients have a long-lasting cough with a copious amount of sputum production which may at times contain blood.

3. Lung abscess and empyema:

Pus collection in the lung parenchyma is called as lung abscess while pus collection in the pleural cavity is called empyema. Patients with lung abscess have very foul smelling sputum production along with swinging fever and chest pain. Patients with empyema have a high-grade fever and chest pain with shortness of breath.

4. Interstitial lung disease:

Idiopathic pulmonary fibrosis is a disease of elderly patients. These patients have a dry cough with progressively worsening dyspnea and clubbing.

Gastrointestinal causes of clubbing:

  1. Inflammatory bowel diseases include ulcerative colitis and Crohn’s disease. In both these conditions, patients present with bloody diarrhea and abdominal pain. Diagnosis requires colonoscopy with biopsy. Treatment is aimed at immunomodulation.

  2. Cirrhosis: fibrosis with regeneration of the liver parenchyma is called cirrhosis. Cirrhosis is one of the most prevalent conditions worldwide. Individuals may develop ascites (fluid in the peritoneal/ abdominal cavity), encephalopathy and bloody vomiting.

Miscellaneous causes:

These include tuberculosis, HIV infections, and graves disease (also called thyroid acropachy).

Hypertrophic pulmonary osteoarthropathy is another condition with clubbing and thickening of the periosteum of the distal phalanx.

It may be misdiagnosed as arthritis initially. it may be idiopathic or associated with lung cancer.

koilonychia or spoon nails
  1. Spoon nails or Koilonychia:

Koilonychia or spoon-shaped nails as the name suggests is the flattening or loss of convexity of the nails. In severe cases, the nails become concave shaped.

These types of nails suggest an underlying diagnosis of iron deficiency anemia.

Patients with iron deficiency may present with progressive pallor, shortness of breath on exertion, palpitation, headache, and craving for non-food items (PICA).

nail changes in hypoalbuminemia and systemic diseases
white nails or leukonychia
  1. Leukonychia – nail diseases clue to low albumin:

Leukonychia or white nails is indirect evidence of reduced albumin (hypoalbuminemia) and proteins (hypoproteinemia) in the body.

Hypoalbuminemia and hypoproteinemia may be found in malnutrition, malabsorption, nephrotic syndrome, and liver diseases.

Patients with liver diseases may have associated pruritis which may lead to shiny nails as well. Leukonychia should be differentiated from the common findings of white lines on the nails or milk line which usually do not have any clinical significance.

nail changes in vasculitis and heart diseases
splinter hemorrhages in infective endocarditis
  1. Splinter hemorrhages or red vertical spots:

Red vertical lines or splinter hemorrhages under the nails develop when microhemorrhages occur under the nails.

These hemorrhages develop when the vessels are fragile as in vasculitis or when clots travel from the heart and block capillaries.

Thus, splinter hemorrhages are usually found in infective endocarditis (infection of the heart valves) and when emboli travel from the heart to distant parts of the body.

nail changes in kidney and systemic diseases
half and half nails in kidney diseases
  1. Half and half nails – nail diseases clue to kidney diseases:

In these type of nails, the white area of the nail i.e the nail bed occupies half of the nail. This is most commonly seen in patients with kidney diseases and especially those on hemodialysis.

terry's nails
terry’s nails in chronic conditions and old age
  1. Terry’s nails:

These nails are almost similar to half and half nails but the whitish area occupies up to 80% of the part. These nails are common in patients with liver diseases, diabetes, kidney diseases and patients with congestive cardiac failure.

nail changes in malnutrition and systemic diseases
beaus lines in malnutrition
  1. Beaus lines – nail diseases in systemic illnesses:

These are horizontal depressions in the nails suggestive of transient growth cessation of the nails. These may also be found in hypocalcemia, coronary occlusion, malnutrition, and trauma.

nail changes in psoriasis and systemic diseases
onycholysis in psoriasis
  1. Onycholysis and pitting of nails:

Separation of nail especially the distal part of the nail from the nail bed is called onycholysis. It can occur in local skin conditions like fungal infections but can also be found in connective tissue disease, hyperthyroidism, and psoriasis. Pitting of the nails is seen in psoriasis and fungal infections.

In Conclusion:

Nail diseases can be a clue to serious systemic diseases. Finding the underlying condition is of utmost importance to prevent the patient from long-term disabilities.

Book appointment here if you have nail diseases or nail changes and systemic symptoms



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